Nattsumi's Epilepsy Diary

Ropireddy Deepak

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CONTRIBUTORS IX

Foreword xiii

Rise of the Machines - On the Threshold of a new Era in Epilepsy Research Daniel H. Lowenstein

Introduction: Applications and Emerging concepts of computational neuroscience in Epilepsy Research xv

Ivan Soltesz and Kevin Staley

PART i

Computational Modeling Techniques and Databases in Epilepsy Research

1 Simulation of Large Networks: Technique and Progress 3

William W. Lytton, Mark Stewart and Michael Hines

2 The NEURON Simulation Environment in Epilepsy Research 18

N.T. Carnevale and Michael Hines

3 The CoCoDat Database: Systematically Organizing and Selecting Quantitative Data on Single Neurons and Microcircuitry 34

Jonas Dyhrfjeld-Johnsen and Rolf Kotter

4 Validating Models of Epilepsy 43

Kevin Staley, Waldemar Swiercz and Krzysztof J. Cios

5 Using NeuroConstruct to Develop and Modify Biologically Detailed 3D Neuronal Network Models in Health and Disease 48

Padraig Gleeson, Volker Steuber and R. Angus Silver

6 Computational Neuroanatomy of the Rat Hippocampus: Implications and Applications to Epilepsy 71

Deepak Ropireddy, Susan E. Bachus, Ruggero Scorcioni and Giorgio a. Ascoli

PART ii

Epilepsy and Altered Network Topology

7 Modeling Circuit Alterations in Epilepsy: A Focus on Mossy

Cell Loss and Mossy Fiber Sprouting in the Dentate Gyrus 89

Vijayalakshmi Santhakumar

8 Functional Consequences of Transformed Network

Topology in Hippocampal Sclerosis 112

Robert J. Morgan and Ivan Soltesz

9 Multiple-Scale Hierarchical Connectivity of Cortical

Networks Limits the Spread of Activity 132

Marcus Kaiser

PART iii

Destabilization of Neuronal Networks

10 Computer Simulations of Sodium Channel Mutations that Cause Generalized Epilepsy with Febrile Seizures Plus 143

Jay Spampanato and Alan L. Goldin

11 Gain Modulation and Stability in Neural Networks 155

Frances s. Chance

12 Neocortical Epileptiform Activity in Neuronal Models with Biophysically Realistic Ion Channels 168

Wim van Drongelen, Amber Martell and Hyong C. Lee

13 Corticothalamic Feedback: A Key to Explain Absence Seizures 184

Alain Destexhe

14 Mechanisms of Graded Persistent Activity: Implications for Epilepsy 215

Erik Fransén

15 Small Networks, Large Networks, Experiment and Theory -Can We bring Them Together with Oscillations, Heterogeneity and Inhibition? 232

Frances K. Skinner and Ernest Ho

PART iv

Homeostasis and Epilepsy

16 Stability and Plasticity in Neuronal and Network Dynamics 247

Astrid a. Prinz

17 Homeostatic Plasticity and Post-Traumatic Epileptogenesis 259

Maxim Bazhenoy, Arthur R. Houweling, Igor Timofeey and Terrence J. Sejnowski part v

Mechanisms of Synchronization

18 Synchronization in Hybrid Neuronal Networks 281

John a. White and Theoden I. Netoff

19 Complex Synaptic Dynamics of GABAergic Networks of the Hippocampus 288

Gianmaria Maccaferri

20 Experimental and Theoretical Analyses of Synchrony in Feedforward Networks 304

Alex. d. reyes

21 Modulation of Synchrony by Interneurons: Insights from Attentional Modulation of responses in the Visual Cortex 317

Paul H.E. Tiesinga and Calin I Buia

PART vi

Interictal to Ictal Transitions

22 Cellular and Network Mechanisms of Oscillations Preceding and Perhaps Initiating Epileptic Discharges 335

Roger D. Traub, Diego Contreras and Miles a. Whittington

23 Transition to Ictal Activity in Temporal Lobe Epilepsy: Insights from Macroscopic Models 356

F. Wendling and p. Chauyel

24 Unified Modeling and Analysis of Primary Generalized Seizures 387

P.A. Robinson, M. Breakspear and J.A. Roberts

25 A Neuronal Network Model of Corticothalamic Oscillations: The Emergence of Epileptiform Absence Seizures 403

Piotr Suffczynski, Stiliyan Kalitzin and F.H. Lopes da Silya

26 Extracellular Potassium Dynamics and Epileptogenesis 419

Flavio Fröhlich, Igor Timofeev, Terrence J. Sejnowski and Maxim Bazhenov

27 Slow Waves Associated with Seizure Activity 440

Anatol Bragin and Jerome Engel Jr

PART vii

Seizure Dynamics

28 Dynamics of Epileptic Seizures during Evolution and Propagation 457

Christophe C. Jouny and Gregory K. Bergey

29 Are Correlation Dimension and Lyapunov Exponents Useful

Tools for Prediction of Epileptic Seizures? 47 1

Ying-Cheng Lai, Ivan Osorio, Mark G. Frei and Mary Ann F. Harrison

30 Towards a Dynamics of Seizure Mechanics 496

Steven J. Schiff, John R. Cressman, Ernest Barreto and JokUbas ^iburkus

PART viii

Towards Computer-aided Therapy

31 Principles and Practice of Computer-aided Drug Design as Applied to the Discovery of Antiepileptic Agents 515

Donald F. Weaver

32 Computation Applied to Clinical Epilepsy and Antiepileptic Devices 530

Javier Echauz, Stephen Wong, Otis Smart, Andrew Gardner, Gregory Worrell and Brian Litt

33 Microelectrode-based Epilepsy Therapy: a Hybrid Neural Prosthesis Incorporating Seizure Prediction and Intervention with Biomimetic Maintenance of Normal Hippocampal Function 559

Michelle L. Stephens, Dennis D. Spencer, IdilCavus, Min-Chi Hsiao,

Dong Song, Sam a. Deadwyler, Robert E. Hampson, David Putz,

Jorge E. Quintero, Meriem K. Bensalem-Owen, Kevin N. Hascup,

Erin C. Rutherford, B. Keith Day, Justin R. Nickell, Francois Pomerleau,

Peter Huettl, Jason J. Burmeister, Pooja M. Talauliker,

Vasilis Z. Marmarelis, John J. Granacki, Theodore Berger and Greg a. Gerhardt

Index

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